Fully customized distillers

from Bram-Cor Pharmaceutical Technologies

Multistage Process Diagram

Heating for evaporation and cooling for condensation processes are performed by double tube sheet (DTS) exchangers. Condensation is achieved by means of the thin-falling film technology.

Safe& sturdy cGMP Construction

Made in Italy, made in Parma: dating back to 1964, our headquarters is located in highly specialized industrial district, heart of the Italian food valley and of the European Food Safety Authority (EFSA).

WFI & Compendial Waters

Water For Injection is classified as an excipient in the production of parenteral preparations and in other pharmaceutical preparations where the endotoxin content must be verified (see related USP, Ph. Eur. and JP pharmacopeia for reference)

BRAM-COR offers a wide range of Multiple Effect Distillation systems. SMPT, our Multiple Effect Distiller, is designed and manufactured according to cGMP to produce compendial Water for Injection.

Each unit contains a number of boiling columns (or effects) with the first column producing pure steam, which is condensed and re-distilled in the following columns, decreasing the operational costs.

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Pharmaceutical Equipment - Turnkey Plants
Pharmaceutical Water Treatment- Bram-Cor

Water Treatments

Producing USP grade waters

Bram-Cor pharmaceutical water treatment systems are designed to produce compendial

PW - Purified Water
WFI - Water For Injection
PS - Pure Steam

Pre-treatment options, monitoring of critical parameters, regulatory requirement for product quality, consumptions, microbiological control, operation and maintenance requirements, lifecycle costs are key points in our design of all processing steps, from feed water to the point of use. Special care is given to the choice of sanitary materials. Product-contact surfaces are in certified AISI 316L stainless steel, with standard roughness ≤ 0.4 µm. EPDM or PTFE gaskets ensure perfect sealing. Advanced Process Analytical Technologies are applied for monitoring issues and professional GAMP compliant automation is provided for system control.

Processing Systems

Processing Systems

Producing IV Fluids & drugs

Bram-Cor designs, manufactures and installs complete Formulation & Preparation Plants starting from specific Product and User Requirements.

Sterile preparation or cleaning and sterilization of process vessels or contact equipment are common issues in the pharmaceutical industry and therefore a must in any of our projects.

Specific manufacturing of solutions or sanitization & sterilization requirements can be satisfied by our processing systems, providing the optimum balance of performance with cost effective aseptic processing equipment through Bram-Cor solutions including:

Mixing Tanks & Formulation Vessels
Bioreactors
CIP/SIP Systems
Filtration Groups
Solutions Transfer Circuits

Filling & Packaging

Filling & Packaging

Plants for Bags & Bottles

Bram-Cor pharmaceutical bags and bottles filling machines offer automatic, semiautomatic or manual options, for different bags or plastic/glass bottle sizes, according to various production needs.

Our equipment ensures trouble-free operation, with reduced maintenance costs and long-term reliability.

Complete bottle lines are integrated with washing machines, capping and crimping machines, labelling lines and belt conveyors.
The range includes:
Filling machines for Bags
Bags making machines
Form-Fill-Seal systems for PP bags
Visual Inspection lines for bags
Plugs/Connectors assembling machines
Filling machines for bottles
Stoppering & Capping systems
Stretch-Blow-Molding machines for PP bottles